Tweetbot feels right at home in OS X with its beautiful interface, animations, support for Retina Displays and Notification Center.
Open saved searches, lists, mentions, direct message conversations and more into columns or windows and never miss a tweet.
Hide tweets that you don’t want to see for a short period or forever. Mute people, hashtags, or tweets via keywords (includes regex).
If you use Tweetbot on iOS, your timeline, unread status, and mute filters will automatically stay in sync so you can always continue where you left off across devices.
Tweetbot supports bitly, CloudApp, Droplr, img.ly, Instapaper, Mobypicture, Pinboard, Pocket, Readability, and yfrog.
Tweetbot is also available on iOS.